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Can Infliximab Reverse My Immunotherapy-Induced Type 1 Diabetes?

Dr Rajiv Kovil |30 Answers |Ask -Follow

Diabetologist - Answered on Dec 10, 2024

Dr Rajiv Kovil is a senior diabetologist, obesity specialist and founder of Zandra Healthcare Private Limited and Rang De Neela, an initiative integrating art with health to promote healing and awareness.
With over 25 years of experience, he has served as an honorary diabetologist Mumbai’s Nanavati Super Specialty Hospital, S L Raheja Hospital and CritiCare Hospital.
A staunch advocate for preventive diabetes care, Dr Kovil co-founded the United Diabetes Forum, a non-profit organisation uniting diabetologists across India to enhance diabetes management.
He is a sought-after speaker at national and international conferences and has authored numerous articles in peer-reviewed journals.
Dr Rajiv earned his MBBS and diploma in diabetology from Topiwala National Medical College, Mumbai.
He remains deeply committed to advancing diabetes care, education and holistic approaches to health through initiatives like Rang De Neela, Blue Dot and Meethas Ek Ehsaas.... more

Asked by Anonymous - Nov 22, 2024Hindi

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I suddenly developed immunotherapy-induced Type 1 Diabetes as a result of 15-month-long Keytruda and Lenvima protocol for recurrence of synchronous ovarian and uterine cancers. My C-Peptide is still producing at low levels. Can Inflixomab potentially reverse my type 1 diabetes? Thank you

Ans: Infliximab is used to treat many autoimmune conditions .
It can help in reducing insulin requirements but cannot put you into a remission

DISCLAIMER: The answer provided by rediffGURUS is for informational and general awareness purposes only. It is not a substitute for professional medical diagnosis or treatment.

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Now a days we are hearing a lot on reversal of diabetes. We hear stories of chronic diabetic patient who were insulin dependant for many years getting free of diabetic medicine in a year's time and also of people who have landed up in ICU's after starting the programme. Can these stories be believed and weather reversal is really possible . Being a diabetic since the last 2 years would like to get a clarity from an expert like you.

Ans: Diabetes remission is a better term than reversal. Patient selection is important and it may not be possible in all. Diet and lifestyle changes are the key, with weight reduction if required. Need guidance with a team of a Doctor and a Registered Dietitan. Initially some medicines may also help with weight and then gradually tapered. Even after remission, regular monitoring may be needed as advised.

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I m suffering from diabetes problem since last 15 years and is on allopathic medicines. Is it reverser able .

Ans: Diabetes can be managed with lowering blood sugar levels by following a healthy lifestyle and dietary modifications. Increasing basal metabolic rate by adapting to a high complex carbohydrate and fiber rich diet, with good protein foods and low total and healthy fats will ensure less spikes in blood sugar levels. Exercises which include building muscle mass and lowering body fat will lower the incidence of hyperglycemia. Avoid processed, canned foods, sweets, alcohol, fatty foods, etc. As the blood sugar levels are lowered, medication doses may need to be altered.

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Question by Suvendra - Nov 15, 2024Hindi

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I was diagnosed with diabetes with HB1AC 8.3. Three months later by proper exercise and right food i controlled it to 6.3. I am doing regular exercise and taking proper food . My diabetes is controlled with normal level . Fasting sugar 105-113 and after taking food it is within 140. Is it advisable to take medications or I will do regular exercises and take proper food.

Ans: I think you should be congratulated for the efforts you have made.

The blood sugar levels are still in range of pre-diabetic. Therefore, it is advisable that while you continue the lifestyle modifications, it will be useful if you take atleast metformin, which works as insulin sensitiser. Once your HbA1c is below 6 and fasting sugar below 100, you can discuss with a physician and stop medications.

However, one of the key factor to determine blood sugar levels is going to be your age. So, if you are younger than 60, remission is a good target.

Dr Chandrakant Lahariya
Centre for Health: The Specialty Practice,
Safdarjung Enclave, New Delhi

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Sir, My father forced me to B-tech engineering degree. I completed my B-tech in chemical engineering in 2008 but our college didn't gave any placementin core chemical. I wanted to go for higher education like M-tech or MBA, but my father didn't make that happen. I gave many interviews from outside in pvt sector and not selected in the final interview. I also qualified in PSUs and same thing happened not qualified in the final selection process. In PSUs also they are wanting higher education. Recently I have done one internship in AI with project from Skillible and one internship in cyber security with project from Edunet foundation. I have 2 years of experience as a math expert in Chegg India. What will I do, please suggest. My father has completely ruined my life.

Ans: Nodody can ruin your career if you have the potential. Your father is not your enemy.
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If higher education was a roadblock before but is now an option, consider pursuing an M.Tech (Chemical/AI/Cybersecurity) or an MBA (Operations, Data Analytics, or IT Management).
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Since you have experience as a math expert at Chegg, you could look at:
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DISCLAIMER: The content of this post by the expert is the personal view of the rediffGURU. Investment in securities market are subject to market risks. Read all the related document carefully before investing. The securities quoted are for illustration only and are not recommendatory. Users are advised to pursue the information provided by the rediffGURU only as a source of information and as a point of reference and to rely on their own judgement when making a decision. RediffGURUS is an intermediary as per India's Information Technology Act.

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