Hi , my wife has rhematoid arthritis for last 5 years . Earlier , her anti CCP was below 10 but now her Anti CCP is gradually increasing and reached 44 and RA factor is 56 . Recently , her CRP has come 5.5 . Pl advice how to control this

Dear Sir, My mother ( 79 yrs.) had sudden onset of constipation & other little bit of gastro-intestinal problems two & half years back. At the same time she complained of pain in the left side of lower abdomen (illiac region). Gastroenrtrologist didn't find any specific serious problem. All tests has been done (USG abdomen, colonoscopy, endoscopy, all bood test,vitamins, TSH, LFT,KFT etc). She was checked by doctor at apollo chennai. They also didn't find any problem with gastro-entrology side. Patient still complaining of pain in left side of lower abdomen, walking difficulties. stifness all over, Pain in left lower limb, pain in the cervical region, both upper limb. Recently one of my friend (Dr.)visited my house. He has diagonised ankle edema, cervical spondyolysis, tunnel carpel syndrome & parkinson & advised me to meet an neurologist. He advised me to do CBC, CRP, Anti-CCP, X-ray of cervical region & nerve conduction study. All are normal except X-ray & NConduction. X-ray shows of spondyolysis & NC study impression : AXONAL TYPE OF SENSORI-MOTOR POLYNEUROPATHY. I met Neorologist He prescribed Pramipex 0.125mg TD for 14 days & then increase the dosage by double. I have started physiotherapy. I She is taking medicine for last four days. I am finding it difficult to manage the situation. Kindly give me some guidance or am i moving in right direction?